刘晶

发布者:花文婷发布时间:2022-11-28浏览次数:13

职称: 副主任药师,副研究员                     E-mail: lygljhit@163.com                          

主要研究方向:心血管药物作用机制研究;心肌细胞损伤标志物研究;micRNALncRNA在心肌细胞缺血再灌注损伤中的机制研究;线粒体动力学及线粒体自噬在心肌细胞损伤中的作用及机制研究;大黄酸对糖尿病心肌病的保护作用机制研究。

 

个人简介

       心血管内科副主任药师,副研究员,南京大学、南方医科大学及5163银河主站线路检测硕士生导师,现为江苏省医学会心血管分会基础与临床药学组委员入选江苏省第五期333工程第三层次培养对象近年以一作及通讯发表SCI论文十余篇,申请国家级课题2江苏省六大人才1项。

 

承担的主要科研项目

1. 国家自然科学基金青年项目:mtDNA在糖尿病心肌细胞损伤中的作用及机制研究  项目批准号 81400238 2015.1-2017.12  23万(第一负责人)结题

2. 国家自然科学基金面上项目:大黄酸对胰岛β细胞Drp1-Pink1/Parki线粒体自噬通路的干预作用研究 项目批准号:81773963 2018.01-2021.12 55万(第一负责人)结题

3.大黄酸通过调节drp1诱导的线粒体自噬保护胰岛β细胞作用机制研究。WSN-093 江苏省六大人才项目 4万 2019.1-2021.12(第一负责人)结题


代表性论文

1. Jing Liu, Zhaohong Chen, Yujing Zhang, Mingchao Zhang, Xiaodong Zhu, Yun Fan, Shaolin Shi, Ke Zen, Zhihong Liu* Rhein protects pancreatic β cells from Drp1-mediated mitochondria dysfunction under hyperglycemia. Diabetes. 2013 Nov;62(11):3927-35. DOI: 10.2337/db13-0251.IF8.3

2. Jing Liu, Ying Zou, Yi Tang, Mingming Xi, Liang Xie, Qigao Zhang, Jianbin Gong*. Circulating cell-free mitochondrial deoxyribonucleic acid is increased in coronary heart disease patients with diabetes mellitus.  J Diabetes Investig. 2016, 7(1): 109-14. DOI: 10.1111/jdi.12366.

3.  Liu JCai XXie LTang YCheng JWang JWang L*, Gong J*. Circulating Cell Free Mitochondrial DNA is a biomarker in the development of Coronary Heart Disease in the patients with type 2 diabetes. Clin Lab. 2015; 61(7):661-7. DOI: 10.7754/clin.lab.2014.141132.

4. Liu J, Zou Y, Tang Y, Xi M, Xie L, Zhang Q, Gong J. Circulating cell-free mitochondrial deoxyribonucleic acid is increased in coronary heart disease patients with diabetes mellitus[J]. J Diabetes Investig. 2016, 7(1): 109-114. DOI: 10.1111/jdi.12366.

5. Xie L, Liu S, Cheng J, Wang L, Liu J*, Gong J*. Exogenous administration of mitochondrial DNA promotes ischemia reperfusion injury via TLR9-p38 MAPK pathway[J]. Regul Toxicol Pharmacol, . 2017, 89:148-154. DOI:10.1016/j.yrtph.2017.07.028(共通讯)

6.   Zhang C, Tang Y, Li Y, Xie L, Zhuang W, Liu J*, Gong J*. Unfolded protein response plays a critical role in heart damage after myocardial ischemia/reperfusion in rats. PloS One. 2017, 12: e0179042. DOI:10.1371/journal.pone.0179042.(共通讯)

7. Chengcheng Zhang, Songqing He, Yanming Li, Feng Li, Zhengbing Liu, Jing Liu*, Jianbin Gon*. Bisoprolol protects myocardium cells against ischemia/reperfusion injury by attenuating unfolded protein response in rat. Sci Rep. 2017, 7(1): 11859. DOI: 10.1038/s41598-017-12366-8.

8. Jing Liu, Yanming Li, Yi Tang, Jinghua Cheng, Jing Wang, Jianhua Li, Xiaohua Ma, Wei Zhuang, Jianbin Gong*, Zhihong Liu* Rhein protects the myocardiac cells against hypoxia/reoxygention-induced injury by suppressing GSK3β activity. Phytomedicine. 51: 1-6.  DOI: 10.1016/j.phymed.2018.06.029.

9. Liang Xie, Songqing He, Na Kong, Ying Zhu, Yi Tang, Jianhua Li, Zhengbing Liu, Jing Liu*, Jianbin Gong*. Cpg-ODN, TLR9 Agonist,  Aggravates Myocardial Ischemia/ Reperfusion Injury by Activation of TLR9-P38 MAPK Signaling. Cell Physiol Biochem. 2018, 47(4): 1389-1398. DOI: 10.1159/000490828(共通讯)

10. Jing Wang, Jing Liu*, Liang Xie, Xiaomin Cai, Xiaohua Ma, Jianbin Gong* Bisoprolol, a β1 antagonist, protects myocardial cells from ischemia reperfusion injury via PI3K/AKT/GSK3β pathway. Fundam Clin Pharmacol. 2020, 34(6): 708-720. DOI: 10.1111/fcp.12562.

11. 姚道敏谢亮宫剑滨朱静刘晶* 基于生物信息学方法分析心肌梗死大鼠miRNA芯片.《中国药理学通报》 2021375673-680

12. 柳丽,季凯琳,徐海玲,曹梦怡,苏丹,刘晶*. 雷公藤甲素对皮质酮诱导小鼠海马神经元细胞损伤的保护作用. 医学研究生学报. 2021;34(11):1138-1143

 




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