颜建明

姓名：颜建明    职称：教授     E-mail：yanjianming1@hotmail.com   

主要研究方向：药物化学、药物合成绿色方法、流动化学辅助的自动化药物合成工艺

个人简介

颜建明，江苏省特聘教授，博士生导师。本科和硕士分别毕业于中国药科大学和中国科学院上海药物研究所（导师，胡立宏教授）。2017年博士毕业于新加坡南洋理工大学（导师，Naohiko Yoshikai），后在新加坡国立大学从事博士后工作（合作导师，吴杰教授），2023年进入5163银河主站线路检测工作。曾作为主要研发人员参与制药企业合作项目：停流微管技术在化学合成中的应用（GSK）、新型连续流装置的辅助下开发氟化反应（Pfizer）。目前已在Nature Communications, J. Am. Chem. Soc., ACS Catalysis, Nature Chemistry等高水平期刊发表论文12篇。

承担的主要科研项目

1. 江苏省特聘教授支持计划，主持，100万，在研

2. 5163银河主站线路检测高层次人才引进科研启动项目，主持，100万，在研

代表性论文

1. Jianming Yan, Haidi Tang, Xiangcheng Shi, Eugene Jun Rong Kuek, Chenguang Liu, Muliang Zhang, Jared L. Piper, Shengquan Duan, Jie Wu. Divergent Functionalization of Aldehydes Photocatalyzed by Neutral Eosin Y with Sulfone Reagents. Nature Communications. 2021, 12. 7214. (IF 14.9, 1区, 2021-Top 25 Chemistry and Materials Sciences Articles in Nature Communications) DOI: 10.1038/s41467-021-27550-8

2.     Jianming Yan, Han Wen Cheo, Wei Kiat Teo, Xiangcheng Shi, Hui Wu, Shabana Binte Idres, Lih-Wen Deng, Jie Wu. A Radical Smiles Rearrangement Promoted by Neutral Eosin Y as a Direct Hydrogen Atom Transfer Photocatalyst. J. Am. Chem. Soc. 2020, 142, 11357–11362. (IF 14.6, 1区).https://pubs.acs.org/doi/10.1021/jacs.0c02052

3.     Jianming Yan,Md. Shafiqur Rahman, Naohiko Yoshikai Pd-Catalyzed Annulation of 1-Halo-8-arylnaphthalenes and Alkynes Leading to Heptagon-Embedded Aromatic Systems. Chemistry – A European Journal 2019, 25, 9395–9399. (IF 4.9, 2区).10.1002/chem.201805746

4.     Jianming Yan, Naohiko Yoshikai. Phenanthrene Synthesis via Chromium-Catalyzed Annulation of 2-Biaryl Grignard Reagents and Alkynes.Org. Lett. 2017, 19, 6630–6633. (IF 6.6,1区).DOI: 10.1021/acs.orglett.7b03342

5.     Jianming Yan, Naohiko Yoshikai. Chromium-Catalyzed Migratory Arylmagnesiation of Unactivated Alkynes. Org. Chem. Front.2017, 4, 1972–1975. (IF 5.1, 1区). DOI: 10.1039/C7QO00427C

6.     Jianming Yan, Naohiko Yoshikai. Cobalt-Catalyzed Arylative Cyclization of Acetylenic Esters and Ketones with Arylzinc Reagents through 1,4-Cobalt Migration. ACS Catal.2016, 6, 3738–3742. (IF 12.2, 1区). DOI: 10.1021/acscatal.6b01039

7.     Jianming Yan, Guan Liang Tay, Cuien Neo, Bo Ra Lee, and Philip Wai Hong Chan. Gold-Catalyzed Cycloisomerization and Diels–Alder Reaction of 1,6-Diyne Esters with Alkenes and Diazenes to Hydronaphthalenes and –cinnolines. Org. Lett.2015, 17, 4176–4179. (IF 6.6；1区). DOI:10.1021/acs.orglett.5b01935

8.     Zhiyuan Zhu, Jianming Yan, Wei Jiang, Xin-gang Yao, Jing Chen, Lili Chen, Chenjing Li, Lihong Hu, Hualiang Jiang, Xu Shen. Arctigenin Effectively Ameliorates Memory Impairment in AD Model Mice Targeting both Aβ Production and Clearance. J. Neurosci. 2013, 33, 13138–13149. (IF 5.9；1区). DOI: 10.1523/JNEUROSCI.4790-12.2013

9.     Xingyu Xu, Chong Li, Min Lei, Zhiyuan Zhu, Jianming Yan, Xu Shen, Lihong Hu. Synthesis and Decreasing Aβ Content Evaluation of Arctigenin-4-yl Carbamate Derivatives. Bioorg. Med. Chem. Lett.2016, 26, 2988–2991. (IF 2.5；3区). DOI: 10.1016/j.bmcl.2016.05.028.

10.  Xuanzi Fan , Muliang Zhang , Qi Zhou , Yanbin Zhang , Yuanjun Gao , Jiajia Yu , Wengang Xu , Jianming Yan , Haiwang Liu , Zhexuan Lei , Yan Chong Ter , Supphachok Chanmungkalakul , YanweiLum, Xiaogang Liu, Ganglong Cui, Jie Wu. Stepwise On-Demand Functionalization of Multihydrosilanes Enabled by Eosin Y-Based Hydrogen Atom Transfer Photocatalysis. 2023,NatureChemistry (https://doi.org/10.1038/s41557-023-01155-8).